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KMID : 0359920090280030248
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Korean Journal of Nephrology
2009 Volume.28 No. 3 p.248 ~ p.252
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A Case of Anti-Glomerular Basement Membrane Disease Improved by Early Plasmapheresis and Immunosuppression Therapy
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Lee Yu-Ji
Jung Hae-Yon
Lee Jung-Eun
Huh Woo-Seong
Kim Dae-Joong
Oh Ha-Young
Kim Yoon-Goo
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Abstract
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Anti-glomerular basement membrane disease is a rare autoimmune disease characterized by rapidly progressive renal failure and/or pulmonary hemorrhage. The presence of severe crescentic glomerular inflammation with linear deposition of immunoglobulin G along the glomerular basement membrane is pathognomonic. Because renal function is rapidly and often irretrievably destroyed, many patients require hemodialysis all through their lifetime. We report a case of 33 year(s)-old man who was diagnosed as anti-glomerular basement membrane disease without pulmonary hemorrhage. The patient was treated with pulse methylprednisolone and plasmapheresis followed by oral corticosteroid and cyclophosphamide. His renal function was successfully recovered with early diagnosis and aggressive treatment.
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KEYWORD
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Anti-glomerular basement membrane disease, Corticosteroids, Plasmapheresis, Cyclophosphamide
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